منابع مشابه
Regulation of pyruvate kinase M gene expression.
t w t r i p s a t p s b f c ransferase, EC 2.7.1.40), a rate-controlling glycolytic nzyme, catalyses the transfer of a phosphoryl group rom phosphoenolpyruvate to ADP, yielding ATP and yruvate. PK exists in the cytosol and is functional as tetramer. Mammalian PK exists as four isoenzymes, hich are referred to as the L-, R-, M1-, and M2-types, espectively (1). The L-, R-, and M1-PK isoenzymes ar...
متن کاملPyruvate Kinase Isozymes from Rat Tissues
Developmental and aging patterns of pyruvate kinase (PK) isozymes (PK 1, PK 2, PK 3, and PK 4) from rat liver, kidney, heart, and skeletal muscle were studied by electrophoretic, chromatographic and immunochemical techniques. During the first 2 weeks of postnatal life a decline of total PK activity occurred in liver, kidney, and heart followed by an increase to adult or higher than adult levels...
متن کاملBiosynthesis of rat liver pyruvate kinase
Sodium dodecyl sulphate/polyacrylamide-gel electrophoresis of immunoprecipitates of liver cytosol with anti-(L-type pyruvate kinase) serum revealed proteins of mol.wt. 56000 and 42000 in addition to the heavy and light chains. The ratio of the 56000mol.wt. to the 42000mol.wt. protein increased under dietary conditions that resulted in an increase in the apparent specific activity of hepatic pyr...
متن کاملEvidence that rat liver pyruvate dehydrogenase kinase activator protein is a pyruvate dehydrogenase kinase.
It is shown here that rat liver pyruvate dehydrogenase (PDH) kinase activator protein (KAP) catalyses ATP-dependent inactivation and [32P]phosphorylation of pig heart PDHE1 and of yeast (Saccharomyces cerevisiae) PDH complex devoid of PDH kinase activity, that fluorosulphonylbenzoyladenosine inactivates rat liver KAP and the intrinsic PDH kinase of rat liver PDH complex, and that KAP, like PDH ...
متن کاملPrevalence of Pyruvate Kinase Deficiency among the Newborns (Shiraz-Iran)
Background: The frequency of pyruvate kinase (PK) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in Shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. The purpose of this study is to obtain data on the frequency and spectrum of gene mutation of PK in newborns, from Shiraz and surrounding areas. Materials and Methods...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)94185-2